Arc - an endogenous neuronal retrovirus?

Shepherd JD (2018). Seminars in Cell & Developmental Biology, 77:73-78.

The neuronal gene Arc encodes a repurposed retrotransposon gag protein that mediates intercellular RNA transfer

Pastuzyn ED, Day CE, Kearns RB, Kyrke-Smith M, Taibi AV, McCormick J, Yoder N, Belnap DM, Erlendsson S, Morado DR, Briggs JAG, Feschotte C, Shepherd JD (2018). Cell, 172:1-2.

Activity-dependent Arc expression and homeostatic synaptic plasticity are altered in neurons from a mouse model of Angelman syndrome

Pastuzyn ED, Shepherd JD (2017). Frontiers in Molecular Neuroscience, 10:234.

Arc restores juvenile plasticity in adult mouse visual cortex

Jenks KR, Kim T, Pastuzyn ED, Okuno H, Taibi AV, Bito H, Bear MF, Shepherd JD (2017). Proc Natl Acad Sci, 114(34):9182-9187.

Deep-brain imaging via epi-fluorescence computational cannula microscopy

Kim G, Nagarajan N, Pastuzyn E, Jenks KR, Capecchi M, Shepherd JD, Menon R (2017). Scientific Reports, 7, 44791.

Arc: building a bridge from viruses to memory

Day C, Shepherd JD (2015). Biochemical Journal, 469(1):e1-3.

Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse

Gee JM, Smith NA, Fernandez FR, Economo MN, Brunert D, Rothermel M, Morris SC, Talbot A, Palumbos S, Ichida JM, Shepherd JD, West PJ, Wachowiak M, Capecchi MR, Wilcox KS, White JA, Tvrdik P (2014). Neuron, 83(5):1058-72.

The role of ionotropic glutamate receptors in childhood neurodevelopmental disorders: autism spectrum disorders and fragile X syndrome

Uzunova G, Hollander E, Shepherd JD (2014). Current Neuropharmacology, 12(1):71-98.

Memory, plasticity, and sleep – a role for calcium permeable AMPA receptors?

Shepherd JD (2012). Frontiers in Molecular Neuroscience, 5:49.

Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation

Wu J, Petralia RS, Kurushima H, Patel H, Jung M, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, Wong PC, Worley PF (2011). Cell, 147(3):615-628.

New views of Arc, a master regulator of synaptic plasticity

Shepherd JD and Bear MF (2011). Nature Neuroscience, 14(3): 279–284.

SRF binding to SRE 6.9 in the Arc promoter is essential for the late phase of LTD in cultured Purkinje cells

Smith-Hicks C, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF, Linden DJ (2010). Nature Neuroscience, 13(9):1082-1089.

Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation

McCurry C, Shepherd JD, Tropea D, Wang K, Bear MF, Sur M (2010). Nature Neuroscience, 13(4):450-7.

Eukaryotic elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc essential for mGluR-LTD

Park S, Park JM, Kim S, Kim JA, Shepherd JD, Smith-Hicks CL, Chowdhury S, Kaufmann W, Kuhl D, Ryazanov AG, Huganir RL, Linden DJ, Worley PF (2008). Neuron, 59(1):70-83.

The cell biology of synaptic plasticity: AMPA receptor trafficking

Shepherd JD, Huganir RL (2007). Annual Review of Cell and Developmental Biology, Vol. 23:613-643.

Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking

Chowdhury S, Shepherd JD, Ojuno H, Lyford G, Petralia R, Plath N, Kuhl D, Huganir RL, Worley PF (2006). Neuron, 52(3):445-59.

Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors

Shepherd JD, Rumbaugh G, Wu J, Chowdhury S, Plath N, Kuhl D, Huganir RL, Worley PF (2006). Neuron, 52(3):475-84.

Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003). Neuron, 39(3):409-21.