Virus-like particles of retroviral origin in protein aggregation and neurodegenerative diseases

Carra S, Fabian B, Taghavi H, Milanetti E, Giliberti V, Ruocco G, Shepherd J, Vendruscolo M, and Fuxreiter M. (2025) Molecular Aspects of Medicine.

Arc – A viral vector of memory and synaptic plasticity

Sullivan K, Ravens, A, Walker, A, and Shepherd JD. (2025) Current Opinion of Neurobiology.

dArc1 controls sugar reward valuation in Drosophila melanogaster

Bervoets S, Jacob M, Devineni A, Mahoney B, Sullivan K, Butts A, Sung H, Einstein J, Metzstein M, Dus M, Shepherd JD, and Caron S. (2025) Current Biology 35 (17): 4188-4198

Arc mediates intercellular tau transmission via extracellular vesicles

Tyagi M, Chadha R, Hoog E, Sullivan K, Walker A, Northrop A, Fabian B, Fuxreiter M, Hyman B, and Shepherd JD (2024) bioRxiv.

Arc mediates intercellular synaptic plasticity via IRSp53-dependent extracellular vesicle biogenesis

Ravens A*, Sullivan K*, Einstein J, Keceli SK, Kicmal T, Tyagi M, Hantak M, Shepherd T, Stewart A, Lyon K, Dharan A, Gallagher T, Campbell E, and Shepherd JD (2024) bioRxiv.

*Equal contribution

PNMA2 forms immunogenic non-enveloped virus-like capsids associated with paraneoplastic neurological syndrome

Xu J, Erlendsson S, Singh M, Regier M, Ibiricu I, Day GS, Piquet AL, Clardy SL, Feschotte C, Briggs JA, and Shepherd JD (2024) Cell 187, 831–845

Implementation and testing of a biohybrid transition microelectrode array for neural recording and modulation

Benozir A, Binder S, Boroomand S, Strathman HJ, Hantak M, Shepherd T, Ehrenhofer A, Zhang H, Shepherd JD, Solzbacher F, Tresco PA, Blair S, Reiche CF, and Fan Y ( 2023). bioRxiv.

Arc regulates a second-guessing cognitive bias during naturalistic foraging through effects on discrete behavior modules

Ravens A, Stacher-Hörndli CN, Emery J, Steinwand S, Shepherd JD, and Gregg C (2023). iScience 26(5):106761

Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates

Donghwi B, Jones RE, Piscopo KM, Tyagi M, Shepherd JD, and Hollien J. (2022). Molecular Biology of the Cell 33 (13): ar125

Scan-less machine-learning-enabled incoherent microscopy for minimally-invasive deep-brain imaging

Guo R, Nelson S, Regier M, Davis MW, Jorgensen EM, Shepherd JD, and Menon R (2022) Optics Express 30 (2): 1546–54.

Intercellular Arc signaling regulates vasodilation

de la Peña JB, Barragan-Iglesias P, Lou TF, Kunder N, Loerch S, Shukla T, Basavarajappa L, Song J, James DN, Megat S, Moy JK, Wanghzou A, Ray PR, Hoyt K, Steward O, Price TJ, Shepherd JD, Campbell ZT (2021). Journal of Neuroscience, 41(37):7712-7726.

The immediate early gene Arc is not required for hippocampal long-term potentiation

Kyrke-Smith M, Volk LJ, Cooke SF, Bear MF, Huganir RL, Shepherd JD (2021). Journal of Neuroscience, 41(19):4202-4211.

Computational cannula microscopy of neurons using neural networks

Guo R, Pan Z, Taibi A, Shepherd JD, Menon R (2020). Optics Letters, 45:2111-2114.

Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression

Beagan JA, Pastuzyn ED, Fernandez LR, Guo MH, Feng K, Titus KR, Chandrashekar H, Shepherd JD, Phillips-Cremins JE (2020). Nature Neuroscience, 23:707-717.

Expanding the AtLAS of non-coding RNA functions in the brain

Regier MJ, Shepherd JD (2020). Cell Research, 30:283-284.

Experience-dependent development and maintenance of binocular neurons in the mouse visual cortex

Jenks K, Shepherd JD (2020). Cell Reports, 30(6):1982-1994.e4.

Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins

Erlendsson S, Morado DR, Cullen HB, Feschotte C, Shepherd JD, Briggs, JAG (2020). Nature Neuroscience, 23:172–175.

Intercellular communication in the nervous system goes viral

Hantak MP, Einstein J, Kearns RB, Shepherd JD (2020). Trends in Neurosciences, 44(4): 248–259.

The microbiota protects from viralinduced neurologic damage through microglia-intrinsic TLR signaling

Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O’Connell RM, Stephens WZ, Shepherd JD, Lane TE and Round JL (2019). eLife, 8:e47117

Interneuron simplification and loss of structural plasticity as markers of aging-related functional decline

Eavri R, Shepherd JD, Welsh C, Flanders G, Bear M, Nedivi E (2018). Journal of Neuroscience, 38:8421-8432.