E-mail: Jason.Shepherd@neuro.utah.edu | Phone: 801-585-6214

Radhika Chadha

Short Biography

Radhika completed her bachelor’s in biotechnology at Jaypee Institute of Information Technology (India) and master’s in biomedical sciences at University College London (UK). She completed her PhD in neuroscience at University of Alabama at Birmingham in the lab of Dr. James H. Meador-Woodruff, where she investigated abnormalities in protein expression, protein complexes, phosphorylation, and kinase activity in the AKT-mTOR signaling cascade in postmortem human brain tissue from schizophrenia subjects, since this pathway plays an important role in learning and memory deficits observed in this mental illness. Now, as a postdoctoral associate, she is studying the role of Arc in learning and memory using animal models.

Publications

Chadha R and Meador-Woodruff JH. Downregulated AKT-mTOR signaling pathway proteins in dorsolateral prefrontal cortex in Schizophrenia, Neuropsychopharmacology, 2020, In press.
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Kapoor NK, Chadha R, Kumar S, Choedon T, Reddy VS, Kumar V. Hepatitis B virus X protein facilitates transport of its mRNA and protein via exosomes leading to modulation of hepatic microenvironment, Virus Research, 2017, 240:166-174.
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Chadha R, Shah R, Mani S. Analysis of reported SCO2 gene mutations affecting cytochrome c oxidase activity in various diseases, Bioinformation, 2014, 10(6): 329-333. Read Article

October 28, 2020 / / - /

Matt Regier

Short Biography

Matt completed his PhD at SUNY Downstate Medical Center, where he investigated the production of new ribosomes in memory consolidation. Now, he is working on the finer details of Arc’s role in learning and memory.

Publications

Regier M, Liang J, Choi A, Verma K, Libien J, Hernández AI (2019) Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment. Neural Plasticity 2019:1–8. Read Article

Allen KD*, Regier MJ*, Hsieh C, Tsokas P, Barnard M, Wolk J, Sacktor TC, Fenton AA, Hernandez AI. (2018) Learning-induced ribosomal RNA is required for memory consolidation in mice—Evidence of differentially expressed rRNA variants in learning and memory PLoS ONE 13:e0203374. *Equal Contribution Read Article

Allen KD, Gourov AV, Harte C, Gao P, Lee C, Sylvain D, Splett JM, Oxberry WC, van de Nes PS, Troy-Regier MJ, Wolk J, Alarcon JM, Hernandez AI (2014) Nucleolar integrity is required for the maintenance of long-term synaptic plasticity. PLoS ONE 9:e104364. Read Article

December 20, 2019 / / - /

Kenneth Lyon

Short Biography

I am an easy-going science enthusiast. I enjoy board games, archery, hiking, and fencing. The family I go home to every night is my dog (Newton), my cat (Tali), and my bird (Raziel). My Ph.D. work focused on visualizing translation in living cellsusing fluorescence microscopy. As a postdoc in Jason Shepherd’s lab I am aiming to establish similar live-cell imaging techniques in neurons to study genes related to plasticity and neurodegenerative diseases.

December 19, 2019 / / - /

Sven Bervoets

Short Biography

I received my PhD in Biochemistry and Biotechnology at the University of Antwerp, Belgium, under the mentorship of Dr. Albena Jordanova. During this time, I studied the role of a cytoplasmic tRNA synthetase and its surprising nuclear role in Charcot-Marie-Tooth neuropathology. I used Drosophila melanogaster to show that both genetic and pharmacological exclusion of the mutant TyrRS protein prevents the disease phenotypes. Now, I pursue my postdoctoral research the Shepherd lab, where I focus on the role of dArc1 in memory and learning. I use Drosophila melanogaster to study such behaviours and the properties of the dArc1 protein in cell signalling.

Publications

Bervoets, S., Wei, N., Erfurth, M. et al. Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy. Nat Commun 10, 5045 (2019) Read Article

Peeters, K., Bervoets, S. et al. Novel Mutations in the DYNC1H1 Tail Domain Refine the Genetic and Clinical Spectrum of Dyneinopathies. Hum Mutat 36(3), 287-91 (2015) Read Article

December 19, 2019 / / - /

Michael Hantak

Short Biography

Mike received his B.S. in Biology and Biochemistry from Illinois State University. There, he studied mechanisms of Listeria monocytogenes cold tolerance in the lab of Brian Wilkinson. He then pursued his Ph.D. with Tom Gallagher at Loyola University Chicago, where he investigated mechanisms of virus-cell entry. Mike is currently elucidating how virus-like Arc capsids transfer RNA between cells, and how these transfers may contribute to long-term information storage.

October 1, 2019 / / - /

Madeleine Kyrke-Smith

Short Biography

Madeleine currently studies the role of Arc in long-term potentiation and long-term depression, synaptic plasticity mechanisms which are believed to underlie the formation and maintenance of memory. This work will extend to investigate how these plasticity mechanisms regulate the structure and function of neuronal networks, or engrams, the physical structure of memories in the brain. She is also a Postdoctoral Fellow BBRF Jeanne Marie Lee Investigator.

August 1, 2017 / / - /