E-mail: Jason.Shepherd@neuro.utah.edu | Phone: 801-585-6214

Mansi Saraf

January 11, 2018 / / - /

Jennifer Ichida

January 10, 2018 / / - /

Nate Yoder

January 10, 2018 / / - /

Jenna Novy

I am a second-year undergraduate student studying biomedical engineering at the University of Utah. Under the guidance of graduate student Andrew Taibi and with funding from the Undergraduate Research Opportunities Program (UROP), I am working to clone an activity-dependent synaptic reporter. My interest in neuroscience extends to the branch of neural engineering, which I hope to specialize in as I continue with my bachelor’s degree.

January 10, 2018 / / - /

Cameron Day

Short Biography

 I received a B.S. in Neuroscience from Texas Christian University in 2008 where I worked in the lab of Gary Boehm, my research was focused on neuroimmune interactions in a mouse model.  I completed my PhD at UT-Southwestern Medical Center in February of 2014 in the lab of Phil Thomas.  My doctoral work centered on investigating the effects of neurotrophin signaling pathways on the expression of proteins involved in ALS pathogenesis.  

Additional Information

March 19, 2014 / / - /

Andrew Taibi

Short Biography

I received my B.S. in Biology from Stony Brook University in New York. I then worked for several years studying the role of early transcription factor REST/NRSF in zebrafish development through the regulation of proneural genes under Prof. Howard Sirotkin. I also was able to study the role of Churchill in early development through its roles in FGF and TGFβ signaling. During this time I was able to earn a Master’s Degree in Biochemistry and Cell Biology under Prof. Bernadette Holdener and Prof. Robert Haltiwanger. To explore a long held interest in the ever changing and infinitely complex mind I am now pursuing my Ph.D. in Neuroscience in the Shepherd lab where I hope to contribute to our growing body of knowledge on the molecular mechanisms of synaptic plasticity and memory.

Publications

Pastuzyn, E.D., Day, C.D., Kearns, R.B., Kyrke-Smith, M., Taibi, A.V., McCormick, J., Yoder, N.,  Belnap, D.M., Erlendsson, S., Morado, D.R., Briggs, J.A.G., Feschotte, C., and Shepherd, J.D. The neuronal gene Arc encodes a repurposed retrotransposon Gag protein that mediates intercellular RNA transfer. Cell. 2018 Jan 11; 172; 1-2. Read Article

Jenks K, Kim T, Pastuzyn ED, Okuno H, Taibi AV, Bito H, Bear MF, Shepherd JD. Arc restores juvenile plasticity in adult mouse visual cortex. PNAS. 2017; 114(34):9182-9187. Read Article

Duncan R, Xie Y, McPherson AD, Taibi AV, Bonkowsky JL, Douglass AD, Dorsky RI. Hypothalamic radial glia function as self-renewing neural progenitors in the absence of Wnt/β-catenin signaling. Development. 2016; 1;143(1);45-53. Read Article

Taibi AV, Mandavawala KP, Noel J, Okoye EV, Milano CR, Martin BL, and Sirotkin HI. Zebrafish churchill regulates developmental gene expression and cell migration. Developmental Dynamics. 2013; 6; 614-621. Read Article

Kok FO, Taibi AV, Wanner SJ, Xie X, Moravec CE, Love CE, Prince VE, Mumm JS, Sirotkin HI. Zebrafish rest regulates developmental gene expression but not neurogenesis. Development. 2012; 139; 3838-48. Read Article

Additional Information

Andrew Taibi CV

March 19, 2014 / / - /

Kyle Jenks

Current Research 

Using in vivo electrophysiology and two photon imaging, Kyle is dissecting the role of Arc in critical period plasticity of the mouse visual cortex, and in developmental forms of plasticity necessary to “tune” neurons to properly respond to and encode visual stimuli in adulthood.

Additional Information

Publications

In Press: Jenks K, Shepherd JD. Experience-dependent development and maintenance of binocular neurons in the mouse visual cortex. Cell Press. TBD Read bioRxiv Preprint

Jenks K.R*, Kim T*, Pastuzyn E.D*, Okuno H, Taibi A.V, Bito H, Bear M.F, Shepherd J.D. Arc restores juvenile plasticity in adult mouse visual cortex. PNAS. 2017 Jul 17; Read Article

Kim G, Nagarajan N, Pastuzyn E, Jenks K.R, Capecchi M, Shepherd J, Menon R. Deep-brain imaging via epi-fluorescence computational cannula microscopy. Scientific Reports. 2017 Mar 20; 7, 44791. Read Article

 

March 19, 2014 / / - /

Elissa Pastuzyn

Current Research 

Elissa studies the molecular function of the immediate-early gene Arc. She is examining how Arc is able to transfer its own RNA, as well as foreign RNA, intercellularly, and how this RNA is expressed and modulated in recipient cells. She utilizes both cultured neurons and cell lines.

Publications

Pastuzyn, E.D., Day, C.D., Kearns, R.B., Kyrke-Smith, M., Taibi, A.V., McCormick, J., Yoder, N.,  Belnap, D.M., Erlendsson, S., Morado, D.R., Briggs, J.A.G., Feschotte, C., and Shepherd, J.D. The neuronal gene Arc encodes a repurposed retrotransposon Gag protein that mediates intercellular RNA transfer. Cell. 2018 Jan 11; 172; 1-2.

Pastuzyn, E.D. and Shepherd, J.D. Activity-dependent Arc expression and homeostatic synaptic plasticity are altered in neurons from a mouse model of Angelman syndrome. Front Mol Neurosci. 2017 Jul 28; 10

Jenks, K.R.*, Kim, T.*, Pastuzyn, E.D.*, Okuno, H., Taibi, A.V., Bito, H., Bear, M.F., and Shepherd, J.D. Arc restores juvenile plasticity in adult mouse visual cortex. Proc Natl Acad Sci U S A. 2017 Aug 22; 114; 34.

Kim, G., Nagarajan, N., Pastuzyn, E., Jenks, K., Capecchi, M., Shepherd, J., and Menon, R. Deep-brain imaging via epi-fluorescence computational cannula microscopy. Sci Rep. 2017 Mar 20; 7

Robinson, J.D., Howard, C.D., Pastuzyn, E.D., Byers, D.L., Keefe, K.A., and Garris, P.A. Methamphetamine-induced neurotoxicity disrupts pharmacologically evoked dopamine transients in the dorsomedial and dorsolateral striatum. Neurotox Res. 2014 Aug; 26; 2.

Pastuzyn, E.D. and Keefe, K.A. Changes in neural circuitry regulating response-reversal learning and Arc-mediated consolidation of learning in rats with methamphetamine-induced partial monoamine loss. Neuropsychopharmacology. 2014 Mar; 39; 4.

Howard, C.D.*, Pastuzyn, E.D.*, Barker-Haliski, M.L., Garris, P.A., and Keefe, K.A. Phasic-like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine-induced partial dopamine denervation. J Neurochem. 2013 May; 125; 4.

Additional Information

Elissa Pastuzyn’s CV

August 9, 2013 / / - /