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2 years ago

#Arc, a master regulator of #synapticplasticity, contains sequence elements related to #retrotransposon Gag genes. Here, 2 studies show that Arc retains retroviral-like capsid-forming ability and can ... See more

2 years ago
The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer

We are very excited to share our latest paper, published in Cell!

The neuronal protein Arc is evolutionarily related to retrotransposon Gag proteins and forms virus-like capsid structures that can transfer mRNA between cells in the nervous system.

2 years ago

The Shepherd Lab will receive funding from an NIH program grant on HIV trafficking! Why is a neuroscience lab interested in viruses? Stay tuned!

Center for the Structural Biology of Cellular Host Elements in Egress, Trafficking and Assembly of HIV

2 years ago
Science on Tap II - Memories Gone Viral

The Shepherd lab will be talking about Memory at Piper Down an Olde World Pub tonight! Come listen if you're in town.

A couple things to note:

1. Bring your bad science jokes for a chance to win a prize.

2. Dress up as your favorite scientist for our costume contest for a chance to win a better prize!

How do the ... See more

3 years ago
The University of Utah

The lab made the University home page!

You've heard it before—as we get older our brain power diminishes. But there might be hope to retain intellectual prowess. Our scientists have discovered a gene that could trigger the ability of ... See more

3 years ago
Arc restores juvenile plasticity in adult mouse visual cortex

Second paper, with authors - Kyle Jenks, Elissa Pastuzyn and Andrew Taibi from the lab.

National Academy of Sciences

3 years ago
Activity-Dependent Arc Expression and Homeostatic Synaptic Plasticity Are Altered in Neurons from a Mouse Model of Angelman Syndrome

It's been a great summer for the lab, with two papers published! Here's the first: lead (and sole!) author - Elissa Pastuzyn

Angelman syndrome (AS) is a neurodevelopmental disorder that results from deletions or mutations in chromosome 15, which usually includes the UBE3A gene. Ube3A protein is an E3 ubiquitin ligase that ... See more

3 years ago

The Shepherd Lab received an amazing score on a recent NIH R01 grant submission that ensures funding for the next 5 years! This all due to the hard work of the lab and is much deserved.

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